deterministic semantic pre-filter

One mechanism. Four screening decisions.

ARBITER screens any candidate space against a patient-derived mechanism: compounds, clinical trials, enrolled records, and responder genotypes. The same coherence layer supports discovery, enrollment, failure analysis, and stratification.

open screening console
4
screening modes
72D
meaning geometry
26MB
deterministic engine
0.70
default threshold
clinical-development coherence layer
Patient biology → mechanism field → candidate space → ranked decision.

Screen compounds before wet lab. Match patients to trials. Audit failed studies. Stratify responder profiles against drug mechanisms.

00patient
01mechanism
02candidate
03coherence
04decision
0.733
KRAS G12C clean profile
0.585
KRAS G12V wrong mutation
platform thesis

One patient-derived mechanism. Multiple candidate spaces.

Instead of building separate tools, ARBITER treats each clinical-development decision as the same computation: compare a mechanism field to a candidate set and rank the fit.

01
Compound Screen
What should advance to wet-lab or organoid validation?
02
Trial Fit
Which trial protocol coheres with this patient state?
03
Failed-Trial Audit
Was the signal diluted by the wrong enrolled population?
04
Stratification
Which patient genotype coheres with this drug mechanism?
05
License Layer
Deploy deterministic screening as a pilot or air-gapped translational workflow.
ARBITER · compound coherence console
ready
Load sample to assemble patient-mechanism query.
screened
0/0
above threshold
0
advance to validation
#compoundscore
ARBITER · patient-trial fit console
ready
Load a sample or describe a patient case.
trials scored
0/0
strong matches
0
semantic fit > 0.65
ARBITER · responder subgroup console
ready
Load sample audit to rank enrolled patients by mechanistic coherence.
records scored
0/0
coherent subgroup
0
above 0.70
#enrolled recordscore
ARBITER · responder fit console
ready
Load a KRAS demo or enter mechanism + profiles.
profiles scored
0/0
top fit
coherence score
#patient profilescore
Ready